›› 2011, Vol. 23 ›› Issue (3): 202-205.doi: 10.3969/j.issn.1004-616x.2011.03.010

• 论著 • 上一篇    下一篇

HIV感染对患者精液质量的影响

侯志伟,李练兵,吕 静,李新生,马明福*   

  1. 重庆市人口和计划生育科学技术研究院,出生缺陷与生殖健康重庆市市级重点实验室,重庆 400020
  • 收稿日期:2010-12-24 修回日期:2011-03-30 出版日期:2011-05-30 发布日期:2011-05-30
  • 通讯作者: 马明福

Semen quality and fertility analysis in HIV patients

HOU Zhi-wei,LI lian-bing,LU Jing,LI Xin-sheng,MA Ming-fu*   

  1. Science and Technology Research Institute of Population and Family Planning in Chongqing City, The Key Laboratory of Birth Defect and Reproductive Health, Chongqing 400020, China
  • Received:2010-12-24 Revised:2011-03-30 Online:2011-05-30 Published:2011-05-30
  • Contact: MA Ming-fu

摘要: 探讨HIV感染对患者精液质量的影响。 方法:收集5例正常男性和23例HIV感染者的精液样本,采用计算机辅助精液分析系统检测精液参数,并分析HIV病毒感染对精液质量的影响。 结果:HIV感染者和正常男性的精液质量比较,精子密度、总数、活力、活率均较对照组显著降低 (P均<0.01),而畸形率显著升高 (P<0.01),HIV感染者精液中CD4+ T淋巴细胞数低于健康男性,CD4+ T淋巴细胞数与精子活率和活力相关 ( r = 0.787和0.770,P<0.01)。 结论:HIV感染对男性的精液质量造成严重损伤,有可能降低患者的生育能力。

关键词: HIV, 精液质量, 生育力

Abstract: To investigate the impact of HIV infection on semen quality and fertility. METHODS:Semen were collected from 5 healthy adult males and 23 HIV-infected males. Then routine semen parameters were measured by computer-assisted semen analysis system. Meanwhile,the influence of virus infection on the semen quality was analyzed. RESULTS:Comparing semen quality between healthy and HIV-infected adults,there was difference in sperm concentration,total sperm count,sperm vitality,sperm motility rate and sperm deformity rate (P<0.01). The sperm concentration and total sperm count were 3 times lower in HIV-infected men. The sperm vitality and sperm motility were 3 fold more in healthy men. The sperm deformity was 2 fold more in HIV-infected men. The CD4+ T lymphocytes count in the semen from HIV-infected men was lower than that from healthy men,and there was significant correlation between CD4+ T lymphocytes count and sperm motility rate and sperm vitality ( r = 0.787 and 0.770,P<0.01). CONCLUSION:HIV infection would seriously impact the semen quality and may decrease the fertility rate.

Key words: HIV, semen quality, fertility