HIV感染对患者精液质量的影响

doi:10.3969/j.issn.1004-616x.2011.03.010

›› 2011, Vol. 23 ›› Issue (3): 202-205.doi: 10.3969/j.issn.1004-616x.2011.03.010

HIV感染对患者精液质量的影响

侯志伟,李练兵,吕静,李新生,马明福*

重庆市人口和计划生育科学技术研究院，出生缺陷与生殖健康重庆市市级重点实验室，重庆 400020

收稿日期:2010-12-24 修回日期:2011-03-30 出版日期:2011-05-30 发布日期:2011-05-30
通讯作者: 马明福

Semen quality and fertility analysis in HIV patients

HOU Zhi-wei，LI lian-bing，LU Jing，LI Xin-sheng，MA Ming-fu*

Science and Technology Research Institute of Population and Family Planning in Chongqing City, The Key Laboratory of Birth Defect and Reproductive Health, Chongqing 400020, China

Received:2010-12-24 Revised:2011-03-30 Online:2011-05-30 Published:2011-05-30
Contact: MA Ming-fu

摘要/Abstract

摘要： 探讨HIV感染对患者精液质量的影响。方法：收集5例正常男性和23例HIV感染者的精液样本，采用计算机辅助精液分析系统检测精液参数，并分析HIV病毒感染对精液质量的影响。结果：HIV感染者和正常男性的精液质量比较，精子密度、总数、活力、活率均较对照组显著降低 (P均＜0.01)，而畸形率显著升高 (P＜0.01)，HIV感染者精液中CD4+ T淋巴细胞数低于健康男性，CD4+ T淋巴细胞数与精子活率和活力相关 ( r = 0.787和0.770，P＜0.01)。结论：HIV感染对男性的精液质量造成严重损伤，有可能降低患者的生育能力。

关键词: HIV, 精液质量, 生育力

Abstract: To investigate the impact of HIV infection on semen quality and fertility. METHODS：Semen were collected from 5 healthy adult males and 23 HIV-infected males. Then routine semen parameters were measured by computer-assisted semen analysis system. Meanwhile，the influence of virus infection on the semen quality was analyzed. RESULTS：Comparing semen quality between healthy and HIV-infected adults，there was difference in sperm concentration，total sperm count，sperm vitality，sperm motility rate and sperm deformity rate (P＜0.01). The sperm concentration and total sperm count were 3 times lower in HIV-infected men. The sperm vitality and sperm motility were 3 fold more in healthy men. The sperm deformity was 2 fold more in HIV-infected men. The CD4+ T lymphocytes count in the semen from HIV-infected men was lower than that from healthy men，and there was significant correlation between CD4+ T lymphocytes count and sperm motility rate and sperm vitality ( r = 0.787 and 0.770，P＜0.01). CONCLUSION：HIV infection would seriously impact the semen quality and may decrease the fertility rate.

Key words: HIV, semen quality, fertility

侯志伟,李练兵,吕静,李新生,马明福*. HIV感染对患者精液质量的影响[J]. , 2011, 23(3): 202-205.

HOU Zhi-wei，LI lian-bing，LU Jing，LI Xin-sheng，MA Ming-fu*. Semen quality and fertility analysis in HIV patients[J]. , 2011, 23(3): 202-205.

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HIV感染对患者精液质量的影响

Semen quality and fertility analysis in HIV patients

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